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● 基于阿替普酶桥接取栓治疗急性大血管闭塞性缺血性卒中的研究结果,对于没有静脉溶栓禁忌症且有资格接受机械取栓的患者,直接取栓未能证实非劣于桥接取栓。因此,当患者同时符合静脉溶栓和机械取栓指征时,应进行桥接取栓。
参考文献:
中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国急性缺血性卒中诊治指南2023. 中华神经科杂志,2024,57(06):523-559.
Majoie CB, et al. Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials. Lancet. 2023;402(10406):965-974.
Tanswell P, et al. Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction. Clin Pharmacokinet. 2002;41(15):1229-45.
Warach SJ, et al. Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice. Stroke. 2022;53(12):3583-3593.
Powers WJ, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418.
Alamowitch S, et al. European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke. Eur Stroke J. 2023;8(1):8-54.
中国卒中学会,《中国卒中学会急性缺血性卒中再灌注治疗指南2024》编写组,王拥军. 中国卒中学会急性缺血性卒中再灌注治疗指南2024. 中国卒中杂志,2024,19(12):1460-1478.
Campbell BCV, et al. Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. N Engl J Med. 2018;378(17):1573-1582.
Altersberger VL, et al. Bridging thrombolysis with tenecteplase versus endovascular thrombectomy alone for large-vessel anterior circulation stroke: a target trial emulation analysis. J Neurol Neurosurg Psychiatry. 2025:jnnp-2024-335325.
Meng X, et al. Tenecteplase vs Alteplase for Patients With Acute Ischemic Stroke: The ORIGINAL Randomized Clinical Trial. JAMA. 2024;332(17):1437-1445.
卓琳,等. 模拟目标试验概念及其关键要素. 中华儿科杂志,2024,62(08):751-751.
Matthews AA, et al. Target trial emulation: applying principles of randomised trials to observational studies. BMJ. 2022;378:e071108.
审批号:SC-CN-16714
有效期至:2026年5月7日
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